Article

1. June/July 2026 Vol 25.3Diamine Oxidase Supplementation for Histamine Regulation in Constipation-Predominant Irritable Bowel Syndrome: A Case Report
   Authors: Oscar Coetzee MS, DCN, Cari Pierce MS
   Abstract:

   Since 2016, irritable bowel syndrome has been defined by a grouping of primary symptoms and no longer requires invasive testing for diagnosis. Abdominal pain related to bowel movements or relieved by having a bowel movement is the primary symptom of this functional gastrointestinal disorder. Through expanding appreciation of functional gastrointestinal disorders and the increasing understanding of gastrointestinal tract-brain interactions, a growing body of research is discussing the symptom overlap between IBS and histamine intolerance, as well as other issues of histamine metabolism and related neuroimmune regulation in the pathophysiology of IBS. Visceral hypersensitivity, exacerbated by increased histamine levels, may disrupt the intricate signaling between the central nervous system and enteric nervous system. This case report illustrates the use of supplemental diamine oxidase combined with trigger food avoidance to nearly completely abate IBS symptoms in a 46-year-old Japanese American female.

   Keywords: case report, irritable bowel syndrome, constipation, diamine oxidase, histamine metabolism, HistaGest-DAO, Symptom Severity Score
   Open Access: Yes
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